H-Leu-Leu-OMe -上海鸿肽生物科技有限公司

164P09

H-Leu-Leu-OMe

纯度：>95%HPLC

储存条价：-20°C，避光，干燥。

另提供从粗品至98%纯度规格，具体请联系我们! 本产品仅用于科学研究，不得用于人体！

产品详情

Cat#:

164P09

序列(三字母)：

H-Leu-Leu-OMe

序列(单字母)：

LLME

分子式:

C13H26N2O3·HBr

分子量:

339.27

CAS#:

16689-14-8

合成方法：

Synthetic

存储条件：

-20 °C，避光，干燥

应用：

Apoptosis & Necrosis'Immunomodulating Agents

产品描述：

H-Leu-Leu-OMe (LLOMe) hydrobromide 是人单核细胞或多形核白细胞产生的 L-亮氨酸甲酯的二肽缩合产物，可选择性消除具有细胞毒性潜能的淋巴细胞。H-Leu-Leu-OMe 也可以诱导溶酶体途径应激。

参考文献:

1. Isolation and characterization of dipeptidyl peptidase IV from human placenta. G.Püschel et al., Eur. J. Biochem., 126, 359 (1982)

2. Identification of genes involved in the suppression of antibody production from human peripheral blood lymphocytes. Y.Aiba et al., Biosci. Biotechnol. Biochem., 70, 966 (2006)

3. Leu-Leu-OMe sensitivity of human activated killer cells: delineation of a distinct class of cytotoxic T lymphocytes capable of lysing tumor targets. D.L.Thiele and P.E.Lipsky, J. Immunol., 137, 1399 (1986)

4. The effect of leucyl-leucine methyl ester on proliferation and Ig secretion of EBV-transformed human B lymphocytes. M.Ohlin et al., Immunology, 66, 485 (1989)

5. Generalized toxicity of L-leucyl-leucine-methyl ester for lymphocyte functions. A.M.Mowat and P.A.Leck, Immunology, 69, 564 (1990)

6. Leucyl-leucine methyl ester-treated haploidentical donor lymphocyte infusions can mediate graft-versus-leukemia activity with minimal graft-versus-host disease risk. M.H.Hsieh et al., Biol. Blood Marrow Transplant., 8, 303 (2002)

7. Antiviral responses following L-leucyl-L-leucine methyl esther (LLME)-treated lymphocyte infusions: graft-versus-infection without graft-versus-host disease. J.Filicko-O’Hara et al., Biol. Blood Marrow Transplant., 15, 1609 (2009)

8. Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells. Thiele DL, et, al. Proc Natl Acad Sci U S A. 1990 Jan;87(1):83-7.

9. The immunosuppressive activity of L-leucyl-L-leucine methyl ester: selective ablation of cytotoxic lymphocytes and monocytes. Thiele DL, et, al. J Immunol. 1986 Feb 1;136(3):1038-48.

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H-Leu-Leu-OMe

纯度：>95%HPLC

储存条价：-20°C，避光，干燥。

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