PACAP-27 (human, mouse, ovine, porcine, rat) -上海鸿肽生物科技有限公司

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192P05

PACAP-27 (human, mouse, ovine, porcine, rat)

H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-NH2

纯度：>95%HPLC

储存条价：-20°C，避光，干燥。

另提供从粗品至98%纯度规格，具体请联系我们! 本产品仅用于科学研究，不得用于人体！

产品详情

Cat#:

192P05

序列(三字母)：

H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-NH2

序列(单字母)：

HSDGIFTDSYSRYRKQMAVKKYLAAVL-NH2

别名：

Pituitary Adenylate Cyclase Activating Polypeptide-27 (human, mouse, ovine, porcine, rat), PACAP-38 (1-27) amide (human, mouse, ovine, porcine, rat)

分子式:

C142H224N40O39S

分子量:

3147.65

CAS#:

127317-03-7

合成方法：

Synthetic

存储条件：

-20 °C，避光，干燥

应用：

Pituitary & Hypothalamic Hormones

产品描述：

PACAP-27 (human, mouse, ovine, porcine, rat) 别名 Pituitary Adenylate Cyclase Activating Polypeptide-27 (human, mouse, ovine, porcine, rat), PACAP-38 (1-27) amide (human, mouse, ovine, porcine, rat)，是 PACAP-38 的 N-末端片段，是一种有效的 PACAP 受体拮抗剂，对大鼠 PAC1，大鼠 VPAC1 和人 VPAC2 的 IC50 值分别为 3 nM，2 nM 和 5 nM。

外观：

White lyophilised solid

溶解性：

Soluble to 1 mg/ml in water

参考文献:

1. Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB. K.Forsberg et al., Proc. Natl. Acad. Sci. USA, 90, 393 (1993)

2. The novel VIP-like hypothalamic polypeptide PACAP interacts with high affinity receptors in the human neuroblastoma cell line NB-OK. A.Cauvin et al., Peptides, 11, 773 (1990)

3. Developmental changes of pituitary adenylate cyclase activating polypeptide (PACAP) and its receptor in the rat brain. I.Tatsuno et al., Peptides, 15, 55 (1994)

4. Differential signal transduction by five splice variants of the PACAP receptor. D.Spengler et al., Nature, 365, 170 (1993)

5. Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer’s disease-like pathology in amyloid precursor protein-transgenic mice. D.Rat et al., FASEB J., 25, 3208 (2011)

6. The two forms of the pituitary adenylate cyclase activating polypeptide (PACAP (1-27) and PACAP (1-38)) interact with distinct receptors on rat pancreatic AR 4-2J cell membranes. P.Robberecht et al., FEBS Lett., 286, 133 (1991)

7. Isolation of a neuropeptide corresponding to the N-terminal 27 residues of the pituitary adenylate cyclase activating polypeptide with 38 residues (PACAP38). A.Miyata et al., Biochem. Biophys. Res. Commun., 170, 643 (1990)

8. The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein. E.Kojro et al., FASEB J., 20, 512 (2006)

9. A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs. C.Kimura et al., Biochem. Biophys. Res. Commun., 166, 81 (1990)

10. Receptors for pituitary adenylate cyclase-activating polypeptide: comparison with vasoactive intestinal peptide receptors. A.Arimura, Trends Endocrinol. Metab., 3, 288 (1992)

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PACAP-27 (human, mouse, ovine, porcine, rat)

纯度：>95%HPLC

储存条价：-20°C，避光，干燥。

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