194P02

H-Phe-Ser-Leu-Leu-Arg-Tyr-NH2

FSLLRY-NH2

FSLLRYamide, (Phe1,Ser2,Tyr6)-Proteinase Activated Receptor 1 (1-6) amide (human), (Phe1,Ser2,Tyr6)-Thrombin Receptor (1-6) amide (human), (Phe1,Ser2,Tyr6)-Coagulation Factor II Receptor (1-6) amide (mouse)

C39H60N10O8

796.97

245329-02-6

Synthetic

-20 °C，避光，干燥

Cardiovascular System & Diseases'Hematology

(Phe1,Ser2,Tyr6)-PAR-1 (1-6) amide (human) 别名 FSLLRYamide, (Phe1,Ser2,Tyr6)-Proteinase Activated Receptor 1 (1-6) amide (human), (Phe1,Ser2,Tyr6)-Thrombin Receptor (1-6) amide (human), (Phe1,Ser2,Tyr6)-Coagulation Factor II Receptor (1-6) amide (mouse)，是一个 PAR-2 拮抗剂。在 PAR-2 受体表达 KNKR 细胞中，(Phe1,Ser2,Tyr6)-PAR-1 (1-6) amide (human) 抑制胰蛋白酶(trypsin)对 PAR-2 的活化作用。对钙信号(calcium signaling)的半抑制浓度(halfmaximal inhibitory concentration, IC50)为 50 µM(IC50 = 50 µM)。相反，SLIGRL-amide (PAR-2 (1-6) amide (mouse, rat) 对 PAR-2 的活化作用不会受到 (Phe1,Ser2,Tyr6)-PAR-1 (1-6) amide (human) 的抑制。