PAR-2 (1-6) amide (mouse, rat) -上海鸿肽生物科技有限公司

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194P09

PAR-2 (1-6) amide (mouse, rat)

H-Ser-Leu-Ile-Gly-Arg-Leu-NH2

纯度：>95%HPLC

储存条价：-20°C，避光，干燥。

另提供从粗品至98%纯度规格，具体请联系我们! 本产品仅用于科学研究，不得用于人体！

产品详情

Cat#:

194P09

序列(三字母)：

H-Ser-Leu-Ile-Gly-Arg-Leu-NH2

序列(单字母)：

SLIGRL-NH2

别名：

SLIGRLamide, Proteinase Activated Receptor 2 (1-6) amide (mouse, rat), Thrombin Receptor-Like 1 (1-6) amide (mouse, rat), Coagulation Factor II Receptor-Like 1 (1-6) amide (mouse, rat), SLIGRL-NH2 Protease-Activated Receptor 2 (PAR2) Agonist

分子式:

C29H56N10O7

分子量:

656.83

CAS#:

171436-38-7

合成方法：

Synthetic

存储条件：

-20 °C，避光，干燥

应用：

Hematology

产品描述：

PAR-2 (1-6) amide (mouse, rat) 别名 SLIGRLamide, Proteinase Activated Receptor 2 (1-6) amide (mouse, rat), Thrombin Receptor-Like 1 (1-6) amide (mouse, rat), Coagulation Factor II Receptor-Like 1 (1-6) amide (mouse, rat), SLIGRL-NH2 Protease-Activated Receptor 2 (PAR2) Agonist，是一种蛋白酶激活受体-2 (PAR-2) 选择性的激动剂。

外观：

White

参考文献:

1. Purification and Some Properties of a Protease from the Sarcocarp of Musk Melon Fruit. M.Kaneda et al., Biosci. Biotechnol. Biochem., 61, 2100 (1997)

2. Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue. M.Saiffeddine et al., Br. J. Pharmacol., 118, 521 (1996)

3. The protease-activated receptor-2 upregulates keratinocyte phagocytosis. E.R.Sharlow et al., J. Cell Sci., 113, 3093 (2000)

4. Proteinase-activated receptor-2 in rat aorta: structural requirements for agonist activity of receptor-activating peptides. M.D.Hollenberg et al., Mol. Pharmacol., 49, 229 (1996)

5. Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle. B.al-Ani et al., Can. J. Physiol. Pharmacol., 73, 1203 (1995)

6. Proteinase activated receptor 2: Role of extracellular loop 2 for ligand-mediated activation. B.Al-Ani et al., Br. J. Pharmacol., 128, 1105 (1999)

7. Behavioral model of itch, alloknesis, pain and allodynia in the lower hindlimb and correlativeresponses of lumbar dorsal horn neurons in the mouse. Akiyama T, et al. Neuroscience. 2014 Apr 25;266:38-46.

8. Perivascular adipose tissue-derived relaxing factors: release by peptide agonists via proteinase-activated receptor-2 (PAR2) and non-PAR2 mechanisms. Li Y, et al. Br J Pharmacol. 2011 Dec;164(8):1990-2002.

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PAR-2 (1-6) amide (mouse, rat)

纯度：>95%HPLC

储存条价：-20°C，避光，干燥。

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