DOTA-(Tyr3)-Octreotate -上海鸿肽生物科技有限公司

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205P05

DOTA-(Tyr3)-Octreotate

4,7,10-Tricarboxymethyl-1,4,7,10-tetraaza-cyclododecan-1-yl-acetyl-D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Cys-Thr-OH (Disulfide bond)

纯度：>95%HPLC

储存条价：-20°C，避光，干燥。

另提供从粗品至98%纯度规格，具体请联系我们! 本产品仅用于科学研究，不得用于人体！

产品详情

Cat#:

205P05

序列(三字母)：

4,7,10-Tricarboxymethyl-1,4,7,10-tetraaza-cyclododecan-1-yl-acetyl-D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Cys-Thr-OH (Disulfide bond)

序列(单字母)：

4,7,10-Tricarboxymethyl-1,4,7,10-tetraaza-cyclododecan-1-yl-acetyl-fCYwKTCT

别名：

DOTATATE, DOTA-(Tyr3,Thr8)-Octreotide, DOTA-[Tyr3] Octreotide Acid (Octreotate)

分子式:

C65H90N14O19S2

分子量:

1435.65

CAS#:

177943-89-4

合成方法：

Synthetic

存储条件：

-20 °C，避光，干燥

应用：

Cancer Research

产品描述：

DOTA-(Tyr3)-Octreotate 别名 DOTATATE, DOTA-(Tyr3,Thr8)-Octreotide, DOTA-[Tyr3] Octreotide Acid (Octreotate)，是一个偶联了 DOTA 的生长抑素(somatostatin)类似物，它可以被用来标记射性核素(radiometal)比如 gallium-67 或 gallium-68, indium-111 和 yttrium-90。DOTA-(Tyr3)-Octreotate 在受体介导的肿瘤显影(tumor imaging)和肽受体靶向的放射性核素(radionuclide)疗法中是一个有用的工具。

外观：

White Powder

参考文献:

1. Recombinant human prorenin from CHO cells: expression and purification. T.F.Holzman et al., J. Protein Chem., 9, 663 (1990)

2. Tyr3-octreotide and Tyr3-octreotate radiolabeled with 177Lu or 90Y: peptide receptor radionuclide therapy results in vitro. A.Capello et al., Cancer Biother. Radiopharm., 18, 761 (2003)

3. Long-term follow-up of renal function after peptide receptor radiation therapy with (90)Y-DOTA(0),Tyr(3)-octreotide and (177)Lu-DOTA(0), Tyr(3)-octreotate. R.Valkema et al., J. Nucl. Med., 46, 83S (2005)

4. Optimising conditions for radiolabelling of DOTA-peptides with 90Y, 111In and 177Lu at high specific activities. W.A.Breeman et al., Eur. J. Nucl. Med. Mol. Imaging, 30, 917 (2003)

5. Successful receptor-mediated radiation therapy of xenografted human midgut carcinoid tumour. L.Kolby et al., Br. J. Cancer, 93, 1144 (2005)

6. Combination radionuclide therapy using 177Lu- and 90Y-labeled somatostatin analogs. Jong M, et, al. J Nucl Med. 2005 Jan;46 Suppl 1:13S-7S.

7. 68Ga-DOTATATE and 123I-mIBG as imaging biomarkers of disease localisation in metastatic neuroblastoma: implications for molecular radiotherapy. Gains JE, et, al. Nucl Med Commun. 2020 Aug 10.

8. Affinity profiles for human somatostatin receptor subtypes SST1-SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use. Reubi JC, et, al. Eur J Nucl Med. 2000 Mar;27(3):273-82.

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DOTA-(Tyr3)-Octreotate

纯度：>95%HPLC

储存条价：-20°C，避光，干燥。

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